1. Does the bye week energize the Huskies or make them rusty? Under Steve Sarkisian, the Huskies have almost always come out of a bye week with a win, going 6-1 in those games, so you'd expect them to be continue that trend and put away the Buffalos. Still, sometimes teams struggle tackling after a bye, and the Dawgs haven't exactly been gangbusters at that this season.
2. Can the Huskies avoid looking past the Buffs? This is a game that since the beginning of the year has been penciled in on the schedule as a W for the Dawgs, and the danger is that they feel that way too. Even the worst teams in a conference like the Pac-12 can jump up and bite you if you don't play a good game -- just rewatch the Apple Cup last year. Let's hope the Dawgs can continue to take things one game at a time and don't get caught looking ahead to UCLA.
3. Is there a chip on Sefo Liufau's shoulder? He's a kid from Tacoma who the Huskies recruited but ultimately went another direction with. Sark has spoken highly of him, and does he have something to show his local team that they missed out on? We've seen a similar attitude from Scott Crichton, and maybe he has an out-of-his-mind game to give the Buffs a shot. He has the talent to.
4. Is the loss of Kasen Williams a factor? The Huskies have built great depth at WR, but none that have shown they can do what Williams has in terms of going up to get a ball and being consistent on back shoulder fades. Colorado is a good team to attempt to integrate the younger guys in against, but there may be a couple plays where Kasen's absence is noticeable.
5. Can Marcus Peters win the matchup with Paul Richardson? Richardson is the best WR the Huskies will see all year, and is one of the best in the country. It will be a true test for Peters, as Richardson has managed to burn teams even though he's the focus of Colorado's offense.